What Is The Relationship Between Serum Folate/Vitamin B12 And MTHFR C677T Genotype?
Transcriptional silencing of tumor suppressor genes by hypermethylation of CpG islands located in the promoter region is very common in human colorectal cancer. Dietary folate/vitamin B12 intake and MTHFR C677T genotype was suggested to protect against colorectal cancer. However, only a few studies have addressed the joint effects of circulating levels of folate/vitamin B12 and the MTHFR C677T genotype on the risk of epigenetic inactivation of specific tumor suppressor genes in CRC patients.
