Mayo Clinic researchers have discovered a protein interaction that may explain how the deadly Huntington’s disease affects the brain. The findings, published in and featured on the cover of the current issue of Human Molecular Genetics, show how the mutated Huntington’s protein interacts with another protein to cause dramatic accumulation of cholesterol in the brain.
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Medivation, Inc. (Amex: MDV) today announced updated clinical development plans and milestones for its three programs in Alzheimer’s disease, Huntington’s disease and hormone-refractory prostate cancer.
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A test using cultured cells provides an effective way to screen drugs against Huntington’s disease and shows that two compounds - memantine and riluzole - are most effective at keeping cells alive under conditions that mimic the disorder, UT Southwestern Medical Center researchers report.”These drugs have been tested in a variety of Huntington’s disease models and some HD human trials and results are very difficult to interpret,” said Dr.
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